Duration of effectiveness of pertussis vaccine: evidence from a 10 year community study

04/29/2017 12:13

http://www.bmj.com/content/296/6622/612.short 

 

Duration of effectiveness of pertussis vaccine: evidence from a 10 year community study 

 
Br Med J (Clin Res Ed) 1988296 doi: https://doi.org/10.1136/bmj.296.6622.612 (Published 27 February 1988)Cite this as: Br Med J (Clin Res Ed) 1988;296:612

Abstract

A 10 year study of whooping cough in a discrete general practice community was performed to assess longitudinally the efficacy of pertussis vaccine from one to seven years after immunisation. Of the 436 cases of whooping cough over 10 years, 326 occurred in children aged 1-7 years. The rate of immunisation was known for each cohort of children born during each year, and the attack rate of whooping cough was thus calculated for those immunised and unimmunised. The attack rates were highest in those cohorts exposed to the epidemics of 1977-9, 1981-3, and 1985-7. The efficacy of the vaccine was calculated as a percentage as (attack rate in unimmunised group—attack rate in immunised group) × 100/attack rate in unimmunised group. It fell from 100% in the first year to 46% in the seventh, being 84% in the fourth and only 52% in the fifth.

Thus the pertussis vaccine or its schedule of use does not seem to provide sufficient herd immunity to prevent outbreaks of whooping cough. Matters might be improved if vaccination against pertussis were included in the preschool immunisation programme.