Duration of Immunity Against Pertussis After Natural Infection or Vaccination (May 2005)

04/29/2017 12:22

http://journals.lww.com/pidj/Abstract/2005/05001/Duration_of_Immunity_Against_Pertussis_After.11.aspx

 

Duration of Immunity Against Pertussis After Natural Infection or Vaccination

Wendelboe, Aaron M. MSPH*; Van Rie, Annelies MD, PhD*; Salmaso, Stefania PhD†; Englund, Janet A. MD‡

Pediatric Infectious Disease Journal: May 2005 - Volume 24 - Issue 5 - pp S58-S61
3. Prevention and Treatment
 
Despite decades of high vaccination coverage, pertussis has remained endemic and reemerged as a public health problem in many countries in the past 2 decades. Waning of vaccine-induced immunity has been cited as one of the reasons for the observed epidemiologic trend. A review of the published data on duration of immunity reveals estimates that infection-acquired immunity against pertussis disease wanes after 4–20 years and protective immunity after vaccination wanes after 4–12 years. Further research into the rate of waning of vaccine-acquired immunity will help determine the optimal timing and frequency of booster immunizations and their role in pertussis control.